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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
4.85
Human Site:
Y296
Identified Species:
10.67
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
Y296
I
I
S
R
I
K
S
Y
S
F
P
K
P
G
H
Chimpanzee
Pan troglodytes
XP_520123
544
61880
Q246
W
A
A
E
K
G
P
Q
R
E
A
L
P
M
D
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
Y296
I
I
S
R
I
K
S
Y
S
F
P
K
P
G
H
Dog
Lupus familis
XP_850411
644
73172
W295
P
G
A
H
P
A
T
W
S
A
G
G
I
I
S
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
P295
K
S
Y
S
F
P
K
P
G
H
K
K
P
A
P
Rat
Rattus norvegicus
Q64725
629
71510
P295
K
S
Y
S
F
P
K
P
G
H
K
K
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
P295
A
P
S
D
D
Q
T
P
F
N
P
Y
V
L
Q
Frog
Xenopus laevis
NP_001083616
609
69575
R291
Q
S
P
A
D
S
M
R
R
N
R
S
S
T
A
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
N288
D
N
Y
S
K
Q
G
N
F
L
D
S
A
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
S440
P
T
P
V
S
P
H
S
H
H
Q
H
P
H
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
D479
R
V
T
P
V
R
R
D
S
P
E
P
P
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
6.6
100
6.6
N.A.
13.3
13.3
N.A.
N.A.
13.3
0
0
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
13.3
100
26.6
N.A.
13.3
13.3
N.A.
N.A.
26.6
0
6.6
N.A.
6.6
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
19
10
0
10
0
0
0
10
10
0
10
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
10
19
0
0
10
0
0
10
0
0
0
10
% D
% Glu:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
0
% E
% Phe:
0
0
0
0
19
0
0
0
19
19
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
10
10
0
19
0
10
10
0
19
0
% G
% His:
0
0
0
10
0
0
10
0
10
28
0
10
0
10
19
% H
% Ile:
19
19
0
0
19
0
0
0
0
0
0
0
10
10
0
% I
% Lys:
19
0
0
0
19
19
19
0
0
0
19
37
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
10
0
10
0
19
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
19
0
% M
% Asn:
0
10
0
0
0
0
0
10
0
19
0
0
0
0
0
% N
% Pro:
19
10
19
10
10
28
10
28
0
10
28
10
64
10
28
% P
% Gln:
10
0
0
0
0
19
0
10
0
0
10
0
0
0
10
% Q
% Arg:
10
0
0
19
0
10
10
10
19
0
10
0
0
0
0
% R
% Ser:
0
28
28
28
10
10
19
10
37
0
0
19
10
0
19
% S
% Thr:
0
10
10
0
0
0
19
0
0
0
0
0
0
10
0
% T
% Val:
0
10
0
10
10
0
0
0
0
0
0
0
10
0
10
% V
% Trp:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
28
0
0
0
0
19
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _